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Fasta format

Precompute file containning sequence description (dna or protein)

Columns with a score below the cut-off are removed from the output alignment.

Calculate a running average over the reliability score of X columns and use this smoothed values to remove unreliable columns from the MSA


  • Dress, Andreas WM and Flamm, Christoph and Fritzsch, Guido and Grünewald, Stefan and Kruspe, Matthias and Prohaska, Sonja J and Stadler, Peter F(2008). Noisy: Identification of problematic columns in multiple sequence alignments . Algorithms for Molecular Biology doi
  • Grunewald, S. and Forslund, K. and Dress, A. and Moulton, V.(2006). QNet: An Agglomerative Method for the Construction of Phylogenetic Networks from Weighted Quartets . Molecular Biology and Evolution doi